Biomeme
Evidence Framework

How Well-Evidenced Is Your Stack?

Not all peptides are created equal. We score each one across four evidence dimensions — human trials, mechanism clarity, mRNA monitoring signal, and safety — so you know exactly where the science stands.

ⓘ For informational purposes only — not medical advice.

Scoring Methodology

Each peptide is scored across 4 dimensions (25 points each, 100 total). Scores are based on published clinical evidence, regulatory status, and Biomeme's proprietary mRNA monitoring assessment.

25

Human Trials

25

Mechanism

25

mRNA Signal

25

Safety

#1
94 A

GLP-1 (Semaglutide)

Incretin Mimetic

FDA-approved with the strongest evidence base of any peptide therapy.
#2
88 A

Testosterone / TRT

Hormone

Well-established hormone replacement with decades of clinical data.
#3
71 B

NAD+ / NMN

Metabolic Cofactor

Promising preclinical data with emerging human trial evidence.
#4
64 B-

Kisspeptin

Reproductive Hormone Peptide

Well-characterized reproductive peptide with growing clinical trial data.
#5
59 B-

SS-31 (Elamipretide)

Mitochondrial-Targeted Peptide

Mitochondria-targeted peptide with Phase II/III clinical trial data.
#6
52 C+

MOTS-c

Mitochondrial-Derived Peptide

Exciting mitochondrial peptide with strong preclinical data but limited human trials.
#7
52 C+

Ipamorelin

Growth Hormone Secretagogue

Selective GH secretagogue with a cleaner side-effect profile than GHRP-6.
#8
51 C+

CJC-1295

Growth Hormone Secretagogue

Long-acting GHRH analog with published human PK data, often stacked with ipamorelin.
#9
41 C

TB-500 (Thymosin Beta-4)

Therapeutic Peptide

Wound-healing peptide with strong animal data but minimal human clinical evidence.
#10
38 C

BPC-157

Therapeutic Peptide

Popular in biohacking communities but evidence is almost entirely from animal studies.
#11
34 D+

Selank

Nootropic Peptide

Russian-developed anxiolytic peptide with limited Western clinical validation.
#12
31 D

Epitalon

Telomere Peptide

Telomerase-activating peptide with intriguing but unvalidated anti-aging claims.
#13
29 D

Semax

Nootropic Peptide

Russian-approved nootropic with limited Western clinical validation.

Why Evidence Grading Matters

The peptide and longevity space is growing rapidly — but so is misinformation. Influencer endorsements and anecdotal reports drive adoption of peptides with little-to-no human clinical data. Our Peptide Evidence Score cuts through the noise with an honest, transparent framework. A C or D grade doesn't mean a peptide is useless — it means the human evidence isn't there yet. And that distinction matters for informed decision-making.

Frequently Asked Questions

What is the Peptide Evidence Score?
A proprietary 100-point scoring framework that objectively grades each peptide across four evidence-based dimensions: human trial evidence (0–25), mechanism clarity (0–25), mRNA monitoring signal strength (0–25), and safety profile (0–25). The score reflects the current state of scientific evidence, not popularity or anecdotal reports.
Why do some popular peptides score low?
Popularity doesn't equal evidence. BPC-157 is extremely popular in biohacking communities but has zero published human clinical trials — all data comes from animal studies. Our scoring framework rewards rigorous human evidence and penalizes reliance on animal-only or anecdotal data. This builds trust by being honest about evidence gaps.
What does the mRNA Monitoring Signal dimension measure?
This dimension reflects whether the peptide's expected molecular targets can be reliably measured through gene expression (mRNA) monitoring. Peptides with well-characterized transcriptomic readouts in human tissue score higher because Biomeme's platform can provide actionable molecular feedback on therapeutic response.
How often is the scoring updated?
Scores are reviewed quarterly as new clinical trial data, regulatory decisions, and transcriptomic research become available. The evidence landscape for peptides evolves rapidly, and our scoring framework adapts accordingly.

Track Your Peptide Response.

Biomeme's transcriptomic monitoring platform measures whether your peptide therapy is engaging molecular targets — with real data, not guesswork.

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