HGH Response
Growth Signaling
Biomeme does not prescribe, supply, recommend or evaluate this therapy. This page describes which genes it acts on, not whether you should take it.
Growth hormone signals through hepatic and peripheral receptors, driving downstream IGF-1 transcription. This page describes the genes involved and what a transcript panel can and cannot say about them.
Tracked Physiological Dimensions
On the Advanced Transcriptomics Dashboard, HGH response is tracked across two primary structural and bioenergetic dimensions.
IGF-1 and Collagen Gene Regulation
HGH binds to hepatic and peripheral tissue receptors, driving the downstream transcription of Insulin-Like Growth Factor 1 (IGF-1). In connective tissues like tendons and ligaments, HGH stimulates collagen (COL1A1, COL3A1) transcription, reinforcing bone and joint structures.
This panel reports the transcription of IGF1, COL1A1, COL3A1, PRKAA1 and MTOR. Note that mTORC1 and AMPK are both regulated by protein phosphorylation rather than by transcript abundance, so their transcript levels do not report pathway activity.
Key Target Genes
Insulin-Like Growth Factor 1 Hypertrophic Signaling
Growth factor transcribed downstream of growth hormone receptor signaling.
Collagen Type I & III Alpha 1 Connective Tissue Integrity
Major structural components of tendons and ligaments. These are connective-tissue transcripts and are not recoverable from a blood draw.
Mechanistic Target of Rapamycin Translational Control
Kinase complex that controls translation rate. It is regulated post-translationally, so MTOR transcript level does not report its activity.
AMP-Activated Protein Kinase Metabolic Homeostasis
Kinase activated under energy stress. Regulated by phosphorylation, not transcript abundance.
The Biomeme Molecular Ecosystem
From deep whole-transcriptome sequencing in the laboratory to rapid point-of-care instrumentation in the field.
High-Depth RNA Sequencing
Processed at One Health Labs, Biomeme's CLIA-certified laboratory, using Illumina NovaSeq high-depth paired-end RNA sequencing. Samples are collected in venous PAXgene blood RNA tubes to stabilize cellular transcription at the moment of draw.
Biomeme/5 Handheld Platform
Beyond central-lab genomics, Biomeme engineers patented, battery-powered real-time PCR instruments. Our deployable hardware brings decentralized molecular detection directly to the field and clinical points of care.
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ABOUT THESE PANELS
Biomeme's wellness transcriptomic panels are general wellness products. They report gene activity to support a healthy lifestyle. They are not intended to diagnose, treat, cure, mitigate or prevent any disease or condition, and they are not a substitute for evaluation by a licensed healthcare professional. Results describe the state of the measured transcripts at the moment the sample was taken.