KPV Peptide
Pathway Genes
Biomeme does not prescribe, supply, recommend or evaluate this therapy. This page describes which genes it acts on, not whether you should take it.
There are no published human clinical trials of this peptide.
KPV is a tripeptide fragment of alpha-melanocyte-stimulating hormone, studied in cell and animal models of inflammation. This page describes the genes those studies implicate and what a transcript panel can and cannot say about them.
Tracked Physiological Dimensions
On the Advanced Transcriptomics Dashboard, KPV peptide activity is mapped primarily to the body's inflammatory signaling index.
Inflammatory Gene Regulation
In human cell lines, KPV inhibits NF-κB activation, with evidence pointing to competition at the importin-α3 binding site on p65 (PMID 18061177).
This panel reports the transcription of IL6, TNF, IL10 and NFKB1. Two limits are worth knowing before reading a result. MUC2 is an intestinal transcript and is not measurable from a blood sample. And there is no published evidence that KPV raises IL-10 — the one rodent study that measured it reported a KPV analogue attenuating the scald-induced rise in IL-10 alongside the pro-inflammatory cytokines (PMID 12052369).
Key Target Genes
Interleukin 6 & Tumor Necrosis Factor Pro-inflammatory Cytokines
Two of the principal pro-inflammatory cytokines. IL-6 drives the hepatic acute-phase response; TNF acts locally on endothelium and immune cells to amplify inflammatory signaling.
Interleukin 10 Anti-inflammatory Cytokines
Anti-inflammatory cytokine that signals through its own receptor via JAK1 and STAT3 to repress further pro-inflammatory transcription.
Nuclear Factor Kappa B Subunit 1 Inflammatory Transcription Factor
Transcription factor central to inflammatory gene expression.
Mucin 2 Mucosal Barrier Integrity
The major secreted mucin of the intestine and the main structural component of the mucus layer lining the gut epithelium.
The Biomeme Molecular Ecosystem
From deep whole-transcriptome sequencing in the laboratory to rapid point-of-care instrumentation in the field.
High-Depth RNA Sequencing
Processed at One Health Labs, Biomeme's CLIA-certified laboratory, using Illumina NovaSeq high-depth paired-end RNA sequencing. Samples are collected in venous PAXgene blood RNA tubes to stabilize cellular transcription at the moment of draw.
Biomeme/5 Handheld Platform
Beyond central-lab genomics, Biomeme engineers patented, battery-powered real-time PCR instruments. Our deployable hardware brings decentralized molecular detection directly to the field and clinical points of care.
Scientific Citations (2)
- [1] Dalmasso G, Charrier-Hisamuddin L, Nguyen HT, Yan Y, Sitaraman S, Merlin D. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008;134(1):166-178.
- [2] Liu DH, Su YP, Zhang W, et al. Downregulation of glucocorticoid receptors of liver cytosols and the role of the inflammatory cytokines in pathological stress in scalded rats. Burns. 2002;28(4):315-320.
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ABOUT THESE PANELS
Biomeme's wellness transcriptomic panels are general wellness products. They report gene activity to support a healthy lifestyle. They are not intended to diagnose, treat, cure, mitigate or prevent any disease or condition, and they are not a substitute for evaluation by a licensed healthcare professional. Results describe the state of the measured transcripts at the moment the sample was taken.