Testosterone / TRT
Androgen Receptor Signaling
Biomeme does not prescribe, supply, recommend or evaluate this therapy. This page describes which genes it acts on, not whether you should take it.
Testosterone signals through the androgen receptor, which regulates transcription in muscle, adipose and bone. This page describes the genes involved and what a transcript panel can and cannot say about them.
Tracked Physiological Dimensions
On the Advanced Transcriptomics Dashboard, testosterone activity is tracked across two primary muscle and metabolic dimensions.
Metabolic Flexibility
Reports transcription of SLC2A4 and the substrate-handling genes.
Musculoskeletal Integrity & Recovery
Reports transcription of IGF1 and TRIM63. Note that these are skeletal-muscle transcripts and are not recoverable at meaningful abundance from a blood draw.
Androgen Receptor Gene Regulation
When testosterone binds to the androgen receptor, it translocates to the nucleus to bind DNA, initiating an anabolic gene transcription program. This program promotes muscle protein synthesis via localized IGF-1 upregulation, while suppressing E3 ubiquitin ligases (MuRF1/TRIM63) that target muscle tissue for breakdown.
This panel tracks circulating leukocyte markers reflecting androgen sensitivity and systemic metabolic response. Note that skeletal muscle transcripts like TRIM63 require muscle tissue biopsies and cannot be recovered from blood draws. Transcript levels are not a measure of clinical efficacy or insulin sensitivity.
Key Target Genes
Androgen Receptor Hormonal Signaling
Drives testosterone-mediated gene transcription in target tissues and circulating leukocytes.
Insulin-Like Growth Factor 1 Hypertrophic Signaling
Drives localized growth factor signaling and cellular anabolism.
Muscle Ring Finger 1 Tissue Degradation (Research Reference)
An E3 ubiquitin ligase studied in muscle tissue biopsies; not recoverable from whole blood.
Glucose Transporter Type 4 Glucose Metabolism
Plays key roles in insulin-stimulated glucose transport and peripheral metabolic response.
The Biomeme Molecular Ecosystem
From deep whole-transcriptome sequencing in the laboratory to rapid point-of-care instrumentation in the field.
High-Depth RNA Sequencing
Processed at One Health Labs, Biomeme's CLIA-certified laboratory, using Illumina NovaSeq high-depth paired-end RNA sequencing. Samples are collected in venous PAXgene blood RNA tubes to stabilize cellular transcription at the moment of draw.
Biomeme/5 Handheld Platform
Beyond central-lab genomics, Biomeme engineers patented, battery-powered real-time PCR instruments. Our deployable hardware brings decentralized molecular detection directly to the field and clinical points of care.
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ABOUT THESE PANELS
Biomeme's wellness transcriptomic panels are general wellness products. They report gene activity to support a healthy lifestyle. They are not intended to diagnose, treat, cure, mitigate or prevent any disease or condition, and they are not a substitute for evaluation by a licensed healthcare professional. Results describe the state of the measured transcripts at the moment the sample was taken.