AR
Androgen Receptor
Also known as: NR3C4, DHTR
Nuclear receptor that mediates testosterone's effects on gene expression.
Biological Function
The androgen receptor is a ligand-activated transcription factor. When testosterone or DHT binds, AR translocates to the nucleus and drives transcription of muscle-specific genes, suppresses myostatin, upregulates follistatin, and modulates metabolic gene programs. AR-mediated gene expression is the primary mechanism through which TRT produces its clinical effects.
Why Biomeme Monitors This Target
Serum testosterone levels tell you how much hormone is circulating — but not whether it's reaching tissues and activating gene expression. Monitoring AR-responsive genes provides functional confirmation that TRT is achieving target tissue engagement, complementing standard blood work.
Expression Context
Activated by testosterone and DHT binding. Expression of AR-responsive genes varies by tissue type. Muscle, bone, and reproductive tissues show the strongest AR-mediated transcriptional programs.
Signaling Pathway
Quick Facts
- Symbol
- AR
- Category
- Hormonal & Reproductive
- Applications
- Wellness, Performance
- Linked Therapies
- 2
Related Targets
Monitor AR Expression.
Biomeme's multiplexed platform can include AR in a custom panel alongside up to 47 other molecular targets — in a single rapid run.
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