BDNF
Brain-Derived Neurotrophic Factor
Key growth factor for neuroplasticity, learning, and mood regulation.
Biological Function
BDNF is the most abundant neurotrophin in the brain, essential for neuronal survival, synaptic plasticity, and memory formation. It binds the TrkB receptor to activate downstream signaling cascades (MAPK, PI3K/AKT, PLCγ) that promote neuronal growth and synaptic strengthening. Peripheral BDNF levels correlate with cognitive function and are reduced in depression and neurodegenerative disease.
Why Biomeme Monitors This Target
BDNF is the primary molecular target claimed by nootropic peptides like Semax and Selank. Monitoring BDNF pathway gene expression in peripheral blood provides indirect evidence of whether these peptides are producing neurotrophin-related molecular changes, though CNS-specific effects remain difficult to assess peripherally.
Expression Context
Upregulated by exercise, learning, and some pharmacological interventions. Downregulated by chronic stress, aging, and depression. Exercise is the strongest known non-pharmacological BDNF inducer.
Signaling Pathway
Quick Facts
- Symbol
- BDNF
- Category
- Neurotrophin & Neuropeptide
- Applications
- Wellness, Performance
- Linked Therapies
- 2
Monitor BDNF Expression.
Biomeme's multiplexed platform can include BDNF in a custom panel alongside up to 47 other molecular targets — in a single rapid run.
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