CYP19A1
Aromatase (Cytochrome P450 19A1)
Also known as: Aromatase, P450arom
Enzyme converting testosterone to estradiol — critical for hormonal balance monitoring.
Biological Function
CYP19A1 (aromatase) catalyzes the conversion of androgens (testosterone, androstenedione) to estrogens (estradiol, estrone). This reaction is the sole source of estrogen in men and the primary source in postmenopausal women. Aromatase activity determines the testosterone-to-estradiol ratio, a critical parameter in TRT management.
Why Biomeme Monitors This Target
For TRT patients, aromatase activity is a key concern — excessive aromatization converts supplemental testosterone into estradiol, potentially causing side effects (gynecomastia, water retention). Monitoring CYP19A1 expression provides molecular insight into aromatization rate, complementing serum estradiol measurements.
Expression Context
Expressed in adipose tissue, brain, bone, and gonads. Expression increases with body fat percentage (adipose aromatase). Suppressed by aromatase inhibitors (anastrozole, letrozole) commonly co-prescribed with TRT.
Signaling Pathway
Quick Facts
- Symbol
- CYP19A1
- Category
- Hormonal & Reproductive
- Applications
- Wellness
- Linked Therapies
- 1
Related Targets
Monitor CYP19A1 Expression.
Biomeme's multiplexed platform can include CYP19A1 in a custom panel alongside up to 47 other molecular targets — in a single rapid run.
Discuss Your Panel