GLP1R
Glucagon-Like Peptide-1 Receptor
Also known as: GLP-1R
Receptor for GLP-1 incretin hormones — the target of semaglutide and tirzepatide.
Biological Function
GLP1R is a G-protein coupled receptor expressed in pancreatic β-cells, the brain, heart, and GI tract. When activated by GLP-1 or GLP-1 receptor agonists, it triggers glucose-dependent insulin secretion, glucagon suppression, delayed gastric emptying, and central appetite reduction. GLP1R signaling also activates CREB-mediated transcription and suppresses NF-κB inflammatory pathways.
Why Biomeme Monitors This Target
GLP1R expression levels and downstream signaling gene activity indicate how sensitively a patient may respond to GLP-1 medications. Monitoring GLP1R pathway genes provides molecular feedback on whether drug-receptor engagement is translating into metabolic gene expression changes.
Expression Context
Constitutively expressed in pancreatic islets. Expression can be modulated by metabolic status, chronic GLP-1 agonist exposure (potential desensitization), and inflammatory signaling.
Signaling Pathway
Quick Facts
- Symbol
- GLP1R
- Category
- Metabolic & Insulin Signaling
- Applications
- Wellness
- Linked Therapies
- 1
Monitor GLP1R Expression.
Biomeme's multiplexed platform can include GLP1R in a custom panel alongside up to 47 other molecular targets — in a single rapid run.
Discuss Your Panel