GLUT4
Glucose Transporter Type 4
Also known as: SLC2A4
Insulin-responsive glucose transporter — the endpoint of metabolic signaling.
Biological Function
GLUT4 is the primary insulin-regulated glucose transporter in muscle and adipose tissue. In response to insulin or AMPK activation, GLUT4-containing vesicles translocate to the cell membrane, enabling glucose uptake. GLUT4 expression and translocation efficiency are key determinants of insulin sensitivity.
Why Biomeme Monitors This Target
GLUT4 is the functional endpoint of metabolic signaling — it is where insulin sensitivity becomes measurable at the gene expression level. For patients on GLP-1 therapy or metabolic peptides like MOTS-c, monitoring GLUT4 reveals whether upstream signaling is successfully translating into improved glucose disposal capacity.
Expression Context
Expressed primarily in skeletal muscle and adipose tissue. Upregulated by exercise and AMPK activation. Expression and translocation are impaired in insulin resistance and type 2 diabetes.
Signaling Pathway
Quick Facts
- Symbol
- GLUT4
- Category
- Metabolic & Insulin Signaling
- Applications
- Wellness, Performance
- Linked Therapies
- 2
Monitor GLUT4 Expression.
Biomeme's multiplexed platform can include GLUT4 in a custom panel alongside up to 47 other molecular targets — in a single rapid run.
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