IGF-1
Insulin-Like Growth Factor 1
Also known as: IGF1, Somatomedin C
Primary mediator of growth hormone's anabolic effects throughout the body.
Biological Function
IGF-1 is a peptide hormone primarily produced by the liver in response to growth hormone stimulation. It mediates most of GH's anabolic effects: muscle protein synthesis, bone growth, and cell proliferation. IGF-1 signals through the IGF-1 receptor to activate PI3K/AKT and MAPK pathways. It works in both endocrine (liver-derived) and autocrine/paracrine (local tissue) modes.
Why Biomeme Monitors This Target
IGF-1 gene expression is the primary transcriptomic readout for growth hormone secretagogues like ipamorelin and CJC-1295. Because serum GH levels are pulsatile and hard to interpret from single blood draws, IGF-1 mRNA provides a more stable and functionally meaningful measure of GH axis activation.
Expression Context
Upregulated by growth hormone, exercise, and adequate nutrition. Expression declines with age (somatopause). Chronically elevated IGF-1 is associated with increased cancer risk.
Signaling Pathway
Quick Facts
- Symbol
- IGF-1
- Category
- Growth Hormone Axis
- Applications
- Wellness, Performance
- Linked Therapies
- 2
Monitor IGF-1 Expression.
Biomeme's multiplexed platform can include IGF-1 in a custom panel alongside up to 47 other molecular targets — in a single rapid run.
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