IL-10
Interleukin 10
Also known as: CSIF
Primary anti-inflammatory cytokine — its expression ratio with pro-inflammatory markers defines sepsis phenotype.
Biological Function
IL-10 is the most potent endogenous anti-inflammatory cytokine. It suppresses the production of pro-inflammatory cytokines (TNF-α, IL-6, IL-1β), inhibits antigen presentation (via HLA-DR downregulation), and promotes regulatory T cell differentiation. While essential for preventing immune-mediated tissue damage, excessive IL-10 production drives the immunoparalysis that makes sepsis patients vulnerable to secondary infections.
Why Biomeme Monitors This Target
The IL-6/IL-10 ratio is one of the most informative transcriptomic metrics in critical care. High IL-6 with low IL-10 indicates hyper-inflammation; high IL-10 with suppressed HLA-DR indicates immunoparalysis. Monitoring both simultaneously with Biomeme's multiplexed platform enables real-time immune phenotyping — determining whether a sepsis patient needs anti-inflammatory or immunostimulatory intervention.
Expression Context
Upregulated as a counter-regulatory response to inflammation. Persistently elevated IL-10 in sepsis indicates immune exhaustion and predicts poor outcomes. Returns to baseline with immune recovery.
Signaling Pathway
Quick Facts
- Symbol
- IL-10
- Category
- Sepsis & Host Response
- Applications
- Sepsis, Host Response, Wellness
- Linked Therapies
- 0
Related Targets
Monitor IL-10 Expression.
Biomeme's multiplexed platform can include IL-10 in a custom panel alongside up to 47 other molecular targets — in a single rapid run.
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