NAMPT
Nicotinamide Phosphoribosyltransferase
Also known as: visfatin, PBEF1
Rate-limiting enzyme in the NAD+ salvage pathway — the gateway to sirtuin activation.
Biological Function
NAMPT catalyzes the conversion of nicotinamide to nicotinamide mononucleotide (NMN), the rate-limiting step in the NAD+ salvage pathway. Since most cellular NAD+ is regenerated through this salvage pathway (not de novo synthesis), NAMPT activity directly determines intracellular NAD+ availability and, consequently, sirtuin activity.
Why Biomeme Monitors This Target
NAMPT is the bottleneck for NAD+ biosynthesis. Monitoring NAMPT expression reveals whether the NAD+ salvage pathway is functional and responsive. For patients taking NMN or NR supplements, NAMPT levels indicate whether the endogenous NAD+ recycling machinery is intact or whether supplementation is compensating for a NAMPT deficiency.
Expression Context
Expression follows circadian rhythms (CLOCK-controlled). Declines with age, contributing to NAD+ depletion in aging tissues. Upregulated by exercise and caloric restriction.
Signaling Pathway
Associated Therapies
Quick Facts
- Symbol
- NAMPT
- Category
- Sirtuin & NAD+ Pathway
- Applications
- Longevity, Wellness
- Linked Therapies
- 1
Related Targets
Monitor NAMPT Expression.
Biomeme's multiplexed platform can include NAMPT in a custom panel alongside up to 47 other molecular targets — in a single rapid run.
Discuss Your Panel