PGC-1α
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha
Also known as: PPARGC1A
Master regulator of mitochondrial biogenesis and energy metabolism.
Biological Function
PGC-1α is a transcriptional coactivator that drives the expression of genes required for mitochondrial biogenesis, oxidative phosphorylation, and fatty acid oxidation. It is activated by SIRT1 (deacetylation) and AMPK (phosphorylation), making it a downstream convergence point for energy-sensing pathways. PGC-1α is particularly important in muscle, brown fat, and brain tissue.
Why Biomeme Monitors This Target
PGC-1α expression is a direct readout of mitochondrial biogenesis — the process of making new mitochondria. For longevity and performance applications, monitoring PGC-1α reveals whether NAD+ supplementation, exercise protocols, or mitochondrial peptides are driving functional mitochondrial adaptation.
Expression Context
Strongly upregulated by endurance exercise, cold exposure, fasting, and SIRT1 activation. Expression declines with age and sedentary lifestyle. One of the most responsive genes to lifestyle intervention.
Signaling Pathway
Quick Facts
- Symbol
- PGC-1α
- Category
- Sirtuin & NAD+ Pathway
- Applications
- Longevity, Performance, Wellness
- Linked Therapies
- 2
Related Targets
Monitor PGC-1α Expression.
Biomeme's multiplexed platform can include PGC-1α in a custom panel alongside up to 47 other molecular targets — in a single rapid run.
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