S100A8
S100 Calcium Binding Protein A8
Also known as: Calgranulin A, MRP8
Neutrophil-derived alarmin — one of the earliest transcriptomic signals of immune activation.
Biological Function
S100A8, together with S100A9, forms the calprotectin heterodimer — one of the most abundant proteins in neutrophils. When released during immune activation, calprotectin acts as a damage-associated molecular pattern (DAMP), amplifying the inflammatory cascade through TLR4 and RAGE receptor signaling. S100A8 is among the very first genes upregulated in the transcriptomic response to infection.
Why Biomeme Monitors This Target
S100A8 is a "first responder" gene — its mRNA rises within hours of immune challenge, often before clinical signs appear. For Biomeme's host response panels, S100A8 provides the earliest detectable signal that the innate immune system has been activated. Combined with CEACAM1 and HLA-DRA, it forms a powerful multi-gene early warning signature.
Expression Context
Massively upregulated within hours of infection, trauma, or sterile inflammation. One of the most highly differentially expressed genes in sepsis transcriptomic studies. Can differentiate bacterial infection from sterile inflammatory responses when combined with other markers.
Signaling Pathway
Quick Facts
- Symbol
- S100A8
- Category
- Sepsis & Host Response
- Applications
- Sepsis, Host Response
- Linked Therapies
- 0
Related Targets
Monitor S100A8 Expression.
Biomeme's multiplexed platform can include S100A8 in a custom panel alongside up to 47 other molecular targets — in a single rapid run.
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