SIRT1
Sirtuin 1
Also known as: SIR2L1
NAD+-dependent deacetylase central to metabolic regulation and aging.
Biological Function
SIRT1 is the most studied member of the sirtuin family of NAD+-dependent deacetylases. It removes acetyl groups from histones and transcription factors, regulating gene expression programs involved in metabolism, stress resistance, inflammation, and cellular senescence. SIRT1 deacetylates PGC-1α to promote mitochondrial biogenesis, p53 to modulate apoptosis, and NF-κB to suppress inflammation.
Why Biomeme Monitors This Target
SIRT1 is the primary molecular readout for NAD+ precursor therapies (NMN, NR). If NAD+ supplementation is working, SIRT1-mediated gene regulation should produce detectable downstream changes. Monitoring SIRT1 target gene expression provides functional evidence that NAD+ levels are actually translating into biological activity.
Expression Context
Activated by caloric restriction, exercise, and NAD+ precursor supplementation. Expression declines with age. Activity is directly dependent on intracellular NAD+ availability.
Signaling Pathway
Quick Facts
- Symbol
- SIRT1
- Category
- Sirtuin & NAD+ Pathway
- Applications
- Longevity, Wellness
- Linked Therapies
- 1
Related Targets
Monitor SIRT1 Expression.
Biomeme's multiplexed platform can include SIRT1 in a custom panel alongside up to 47 other molecular targets — in a single rapid run.
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