SIRT3
Sirtuin 3
Mitochondrial sirtuin governing oxidative metabolism and ROS defense.
Biological Function
SIRT3 is the primary mitochondrial NAD+-dependent deacetylase. It regulates nearly every major pathway in mitochondrial metabolism: fatty acid oxidation, the TCA cycle, electron transport chain function, and ROS detoxification. SIRT3 deacetylates SOD2 to enhance antioxidant defense and activates key enzymes in oxidative phosphorylation.
Why Biomeme Monitors This Target
While SIRT1 is the nuclear/cytoplasmic longevity sirtuin, SIRT3 is the mitochondrial counterpart. Monitoring SIRT3 provides a direct readout of mitochondrial metabolic health — critical for longevity applications. SIRT3 activity declines with age and is restored by exercise, caloric restriction, and NAD+ precursors.
Expression Context
Highly expressed in metabolically active tissues (heart, liver, muscle, brain). Upregulated by exercise, fasting, and NAD+ precursors. Expression declines significantly with age.
Signaling Pathway
Associated Therapies
Quick Facts
- Symbol
- SIRT3
- Category
- Sirtuin & NAD+ Pathway
- Applications
- Longevity, Performance
- Linked Therapies
- 1
Related Targets
Monitor SIRT3 Expression.
Biomeme's multiplexed platform can include SIRT3 in a custom panel alongside up to 47 other molecular targets — in a single rapid run.
Discuss Your Panel