Angiogenesis & Tissue Repair WellnessPerformance

VEGF

Vascular Endothelial Growth Factor A

Also known as: VEGFA, VPF

Master regulator of blood vessel formation and tissue repair.

Biological Function

VEGF is the primary signaling protein that stimulates the formation of new blood vessels (angiogenesis). It binds to VEGFR2 receptors on endothelial cells, triggering proliferation, migration, and tube formation. VEGF is critical in wound healing, tissue repair after injury, and exercise adaptation. It is also a key factor in tumor angiogenesis, making it one of the most studied genes in both oncology and regenerative medicine.

Why Biomeme Monitors This Target

Monitoring VEGF expression provides direct molecular evidence of whether tissue repair peptides (like BPC-157 or TB-500) are engaging their proposed angiogenic mechanism. Without VEGF upregulation, the core healing claim of these peptides is unsupported at the molecular level.

Expression Context

Upregulated in response to tissue injury, hypoxia, and exercise. Downregulated in healthy, resting tissue. Chronically elevated VEGF can indicate pathological angiogenesis.